PeptideAI®
Advanced Peptide Design Engine

AI-powered design and optimization for cyclic and linear peptides. From discovery to GMP manufacturing.

Request Quote Our Services
Hours-Days
Rapid Turnaround
cGMP
Certified
Wet-Lab
Validated

AI-Powered Peptide Design

Computational design for cyclic and linear peptides

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Lead Generation

  • Peptide Scaffold Library Screening
  • Cyclic Peptide Design
  • Stapled Peptide Generation
  • Peptide Mimetic Discovery
  • Bioactive Peptide Identification
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Lead Optimization

  • Stability & Half-life Enhancement
  • Cell Penetration Optimization
  • Proteolytic Resistance Prediction
  • Immunogenicity Assessment
  • Skin Permeability Prediction
  • Oral Bioavailability Engineering
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Target Binding Optimization

  • Peptide-Protein Interaction Modeling
  • Binding Affinity Optimization
  • Conformational Stability Analysis
  • Multi-epitope Targeting
  • Receptor Selectivity Enhancement
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Manufacturability & Delivery

  • Synthesis Route Optimization
  • Formulation Stability Prediction
  • Aggregation Propensity Analysis
  • Delivery System Compatibility
  • Cosmetic Formulation Integration

Contract Research Organization (CRO)

End-to-end peptide discovery and development services

Discovery & Screening

  • High-throughput peptide library design (10⁶ - 10⁹ compounds)
  • Phage display, mRNA display, OBOC screening
  • SPR, ITC, and MST binding assays
  • Cell-based functional assays
  • Target validation and hit identification
  • Structure-activity relationship (SAR) studies

Lead Optimization

  • Medicinal chemistry optimization (50-100 analogs)
  • PK/PD profiling in vitro and in vivo
  • Metabolic stability (plasma, liver microsomes)
  • Caco-2 permeability and P-gp efflux
  • hERG and cytotoxicity assays
  • Serum stability and proteolytic resistance

Analytical Development

  • LC-MS/MS method development and validation
  • HPLC purity and identity analysis
  • Amino acid analysis and peptide mapping
  • Circular dichroism (CD) for secondary structure
  • NMR structure elucidation
  • Stability-indicating methods (ICH guidelines)

Preclinical Studies

  • In vivo efficacy studies (mouse, rat models)
  • PK profiling (oral, IV, SC administration)
  • Toxicology studies (acute, sub-chronic)
  • Immunogenicity assessment
  • Tissue distribution and biodistribution
  • GLP-compliant study management

Formulation Development

  • Lyophilized and liquid formulations
  • Excipient screening and compatibility
  • pH and buffer optimization
  • Accelerated and long-term stability (ICH)
  • Freeze-thaw and shipping stability
  • Controlled-release and depot formulations

Regulatory Support

  • CMC documentation for IND/CTA filing
  • Quality Target Product Profile (QTPP)
  • Critical Quality Attributes (CQA) definition
  • Regulatory strategy consultation
  • FDA/EMA pre-IND meeting preparation
  • Post-approval changes (PAS/CBE)

Contract Development & Manufacturing (CDMO)

cGMP peptide synthesis from milligrams to kilograms

Process Development

  • SPPS optimization (Fmoc/Boc strategies)
  • Solution-phase cyclization and ligation
  • Chemoselective coupling (native chemical ligation, click chemistry)
  • Purification method development (prep-HPLC, crystallization)
  • Yield improvement and cost reduction
  • Scale-up feasibility studies (mg → g → kg)

GMP Manufacturing

  • Phase I materials (10-100g scale)
  • Phase II materials (100g-1kg scale)
  • Phase III/Commercial (multi-kg scale)
  • cGMP-compliant cleanrooms (ISO 7/8)
  • Batch record and deviation management
  • Change control and CAPA procedures

Quality Control

  • Release testing per USP/EP/JP monographs
  • Identity (amino acid analysis, MS, NMR)
  • Purity (HPLC ≥95%, peptide mapping)
  • Water content (Karl Fischer)
  • Residual solvents (GC-MS)
  • Endotoxin (LAL), bioburden, sterility

Quality Assurance

  • QP certification and batch release
  • Certificate of Analysis (CoA)
  • Stability studies (ICH Q1A/Q5C)
  • Supplier qualification and audits
  • Annual Product Reviews (APR)
  • FDA/EMA inspection readiness

Advanced Capabilities

  • Disulfide bond formation and optimization
  • Post-translational modifications (PEGylation, glycosylation)
  • Conjugation (drug-linker, antibody-drug conjugates)
  • Lipidation and acylation
  • Isotope labeling (¹³C, ¹⁵N, ²H)
  • Peptide-polymer conjugates

Fill & Finish

  • Aseptic filling (vials, syringes, cartridges)
  • Lyophilization cycle development
  • Vial washing, depyrogenation, sterilization
  • Visual inspection (manual and automated)
  • Serialization and track-and-trace
  • Cold-chain packaging and shipping

Custom Manufacturing Solutions

From FTE-based process development to full cGMP manufacturing campaigns

Discuss Your Project

Therapeutic Applications

Peptide solutions across disease areas

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Oncology

Tumor-targeting peptides, apoptosis inducers, immune checkpoint modulators, and cell-penetrating delivery vectors for intracellular targets.

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Immunology

Immunomodulatory peptides, T-cell epitopes, immune checkpoint inhibitors, and peptide-based therapeutics for autoimmune disorders.

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Vaccines

Multi-epitope vaccines, adjuvant peptides, cancer vaccines, and next-generation immunogens for infectious disease prevention.

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Diagnostics

Peptide biomarkers, imaging agents, biosensors, and diagnostic tools with high specificity for early disease detection.

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Metabolic Disorders

GLP-1 analogs, insulin sensitizers, lipid metabolism modulators, and peptide therapeutics for diabetes and obesity.

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Cosmeceuticals

Anti-aging peptides, skin barrier enhancement, collagen stimulation, and delivery optimization for cosmetic formulations.

Why Choose cyclicpeptide.ai?

1

Structure-based & sequence-based design

Dual computational approach combining physics-based molecular dynamics with machine learning sequence optimization for superior candidates

2

Wet-lab validated

All in silico predictions validated in our cGMP-compliant laboratories with comprehensive analytical characterization

3

Ultra-high throughput

Screen millions of peptide candidates computationally before synthesis, reducing discovery timeline from months to weeks

4

Rapid Turnaround: hours to days

Industry-leading computational design speed with streamlined synthesis and testing workflows for faster program advancement

Infrastructure & Capabilities

🖥️ AI/ML Platform

Deep learning models trained on 10⁶+ peptide-protein complexes for binding prediction, ADMET profiling, and de novo design

🔬 Synthesis Suite

Automated SPPS (Prelude, Liberty Blue), solution-phase cyclization, and preparative HPLC purification systems

📊 Analytical Lab

LC-MS/MS (Orbitrap, QTOF), NMR (600 MHz), SPR (Biacore), CD spectroscopy, and amino acid analyzers

🧫 Cell Culture

BSL-2 facilities for cell-based assays, primary cell isolation, and 3D cell culture systems for efficacy screening

🏭 cGMP Facility

ISO 7/8 cleanrooms with segregated synthesis, purification, lyophilization, and fill-finish capabilities

✅ Regulatory

QP-certified with FDA DMF, EMA compliance, and experience supporting 5+ IND/CTA filings

Partner With Us

Let's accelerate your peptide therapeutics program

Request a Quote

Our team will respond within 24 hours with a detailed proposal

Email: info@ainno.ai
Address: 1309 Coffeen Avenue STE 1200
Sheridan, Wyoming 82801
Website: cyclicpeptide.ai